Coupled dynamics of intestinal microbiome and immune system—A mathematical study

In this study, we develop a simple mathematical model describing the dynamic interaction of T helper cells, Treg cells, and Treg-inducing intestinal microbes. The proposed model may have multiple stable equilibria, and the allergic response is intense at the dysbiotic equilibrium, in which the Treg-inducing microbes are scarce. First, we search for the condition by getting rid of the stable dysbiotic steady state. Further, we examine different methods to reduce the allergic response at the equilibrium (which may be dysbiotic or non-dysbiotic). Furthermore, we discuss the possible therapeutic interventions focusing on the intestinal microbiome to suppress the allergic immune responses. (Source: Journal of Theoretical Biology)

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