GSE123241 Single cell RNA-Seq reveals Fgf signaling dynamics during sensory hair cell regeneration

Contributors : Daniel C Diaz ; Sungmin Baek ; Helena Boldt ; Anoja Perera ; Kate Hall ; Allison Peak ; Jeffrey S Haug ; Tatjana PiotrowskiSeries Type : Expression profiling by high throughput sequencingOrganism : Danio rerioLoss of sensory hair cells leads to deafness and balance deficiencies. In contrast to mammalian hair cells, zebrafish ear and lateral line hair cells regenerate from poorly characterized, proliferating support cells. Equally ill-defined is the gene regulatory network underlying the progression of support cells to cycling hair cell progenitors and differentiated hair cells. We used single-cell RNA-Sequencing (scRNA-Seq) of lateral line sensory organs and uncovered five different support cell types, including quiescent and activated stem cells. In silico ordering of suppo...

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