Τετάρτη 9 Ιανουαρίου 2019

Impact of lymph node sampling on survival in cN0 major salivary gland adenoid cystic carcinoma

Abstract

Background

The role of elective neck dissection in the management of major salivary gland adenoid cystic carcinoma is unclear.

Methods

Data were retrospectively extracted from the National Cancer Center Database. The study cohort included 1504 patients with adenoid cystic carcinoma of major salivary glands with clinical N0 necks who were treated with surgery between 2004 and 2014. The cohort was divided into four groups based on number of lymph nodes (LNs) examined on pathology: 0, 1‐8, 9‐17, and ≥18 LNs.

Results

The rate of occult nodal metastasis was 9.0%. Number of LNs removed was not associated with survival (Reference, 0 LNs; HR = 0.98, 95% CI 0.73‐1.32 for 1‐8 LNs; HR = 1.22, 95% CI 0.80‐1.88 for 9‐17 LNs; HR = 0.94, 95% CI 0.61‐1.46 for ≥18 LNs) after adjusting for important covariates.

Conclusions

LN sampling is not associated with survival in cN0 major salivary gland ACC.



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