Characterization and Comparison of Human LAD1 Mast Cells with Human LAD2 Mast Cells

LAD2 human mast cells were developed over 15 years ago and have been distributed worldwide for studying proliferation, receptor expression, mediator release/inhibition and signaling. LAD2 cells were derived from CD34+ cells following marrow aspiration of a patient with aggressive mastocytosis. Another aspiration gave rise to the cell line LAD1 which has been under liquid N2 and not distributed due to the availability of LAD2. LAD1 cells were recently thawed for study. We queried whether LAD1 had unique properties for the study of human mast cell biology (Source: Journal of Allergy and Clinical Immunology)

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