Comparative characterization of two galectins excreted-secreted from intestine-dwelling parasitic versus free-living females of the soil-transmitted nematode Strongyloides

Publication date: October 2018Source: Molecular and Biochemical Parasitology, Volume 225Author(s): Dana Ditgen, Emmanuela M. Anandarajah, Anika Reinhardt, Abuelhassan Elshazly Younis, Susanne Witt, Jan Hansmann, Eva Lorenz, Marisela García-Hernández, Daniela Paclik, Hanns Soblik, Abbas Jolodar, Peter H. Seeberger, Eva Liebau, Norbert W. BrattigAbstractHelminths are complex pathogens that ensure their long-term survival by influencing the immune responses of their host. Excretory/secretory products (ESP) can exert immunoregulatory effects which foster parasite survival. Galectins represent a widespread group of β-galactoside-binding proteins which are involved in a multitude of biological processes operative in parasite-host interaction. We had earlier identified seven galectins in Stron...

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