Reduced CD8 + T cells infiltration can be associated to a malignant transformation in potentially malignant oral epithelial lesions

ConclusionsCD8+ cells infiltrate more in OPML-NOSCC than in OPML-OSCC. Carcinoma is more infiltrated by CD8+ cells than its associated OPML.Clinical relevanceUnderstanding immunological factors associated with malignant transformation of oral premalignant lesions can open a new way to treat this disease. (Source: Clinical Oral Investigations)

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