High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells [Immunology and Inflammation]

T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ structures dedicated to antibody production. As such, follicular T (Tfol) cells are supposed to be specific for immunizing antigens, which has been reported for Tfh cells but is debated... (Source: Proceedings of the National Academy of Sciences)

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