Δευτέρα 24 Σεπτεμβρίου 2018

Validation of Medicinal Herbs for Anti-tyrosinase Potential

Publication date: Available online 24 September 2018

Source: Journal of Herbal Medicine

Author(s): Pulok K. Mukherjee, Rajarshi Biswas, Akanksha Sharma, Subhodip Banerjee, Sayan Biswas, C.K. Katiyar

Abstract

Tyrosinase is a key regulatory multifunctional enzyme containing copper that is responsible for the biosynthesis of melanin that determines the color of the skin. Accumulation of excessive melanin causes various dermatological disorders including melasma and age spots. Also, tyrosinase is responsible for enzymatic browning reactions in damaged fruits and vegetables. It deteriorates the color clarity of plant-derived food product which results in loss of nutritional quality. The study of Tyrosinase inhibition is an active field of research in dermatological, biomedical, food and agricultural science and also has potential impact in the domain of insect physiology. Despite several developments on tyrosinase inhibitors, their safety concern still requires investigations due to their undesirable side-effects. Research in this context is being carried out to find potent and safe leads as tyrosinase inhibitors from medicinal plants. This review provides comprehensive overviews of various tyrosinase inhibitors obtained from medicinal plants with their mechanism of action. Several medicinal plants as tyrosinase inhibitors have been extensively studied and successfully marketed. The polyphenol and stilbenes group of phyto-molecules have been established as effective tyrosinase inhibitors. Few of these molecules however have been clinically investigated in the context of potential anti-melanogenic medicinal plants. Tyrosinase inhibitors are commercially available for cosmetic purposes to lighten the complexion. Clinically, they are also used in the treatment of hyper-pigmentary disorders. They are equally applicable for the anti-browning agents in the food-processing industry. This review will be useful for the development and evaluation of tyrosinase inhibitors from medicinal plants.

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