Age-dependent loss of induced regulatory T cell function exacerbates liver ischemia-reperfusion injury

Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Rui Liu, Shaopeng Zhang, Wenxuan Ma, Hao Lu, Ji Gao, Xiaojie Gan, Zheng Ju, Jian Gu, Ling LuAbstractPrevious studies demonstrate that the number of induced regulatory T cells (iTregs) increases in aged mice. However, these studies do not characterize iTregs across different ages or how these immune modulators contribute to the dysregulation of immunity in murine disease models. Therefore, this study aimed to examine the relationship between age and iTreg function using a mouse model of hepatic ischemia-reperfusion injury (IRI). In this model, aged-mice suffered more serious injury than Young-mice, with higher serum levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) and higher histol...

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