Allergen-induced exacerbations are associated with remodeling and loss of lung function. Repetitive exposure to cat dander activates TLR-NF κB signaling. Persistent activation results in epigenetic reprogramming, mesenchymal transition and myofibroblast expansion through the BRD4 histone acetyltransferase. (Source: Journal of Allergy and Clinical Immunology)
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