Παρασκευή 26 Οκτωβρίου 2018

The role of dietary sodium in autoimmune diseases: The salty truth

Publication date: November 2018Source: Autoimmunity Reviews, Volume 17, Issue 11Author(s): Kassem Sharif, Howard Amital, Yehuda ShoenfeldAbstractAutoimmune diseases are a group of heterogeneous condition that occur secondary to the intrinsic loss of tolerance to self- antigens. In genetically susceptible individuals, the complex interplay of environmental factors and epigenetic deregulations have been proposed to drive disease etiopathogenesis. Various environmental variables have been identified including viral infections, exposure to pollutants, stress and dietary factors. Sodium, a major constituent of salt is essential for mammalian physiology. However, high salt intake may play a role in the development of autoimmune diseases. Several lines of evidence point toward the role of high so...

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