Biosynthesis of sorafenib coated graphene nanosheets for the treatment of gastric cancer in patients in nursing care

Publication date: Available online 20 November 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Xiaoyue Xu, Xiaoyu Tang, Xiaoxu Wu, Xiufang FengAbstractSorafenib (SRF) is a well-known tyrosine kinase inhibiting anticancer drug which iseffectual against multiple carcinomas especially gastric cancers by targeting the Ras/Raf/Mek/Erk cascade pathway and blocking the tumor cell proliferation. In the present work, we have reduced graphene oxide (GO) in presence of sorafenib using ascorbic as green reducing agent for the treatment of gastric cancers. Sorafenib reduced graphene oxide (SRGO) were obtained with a transparent and smoothmorphology. The drug loaded SRGO has presented significant cytotoxic effect against SGC7901 cancer cells when compared to that of the free ...

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