Characterization of the thymus in Lrp4 myasthenia gravis: Four cases

Publication date: Available online 8 November 2018Source: Autoimmunity ReviewsAuthor(s): Inga Koneczny, Dorit Rennspiess, Florit Marcuse, Myurgia Abdul Hamid, Marina Damas, Jos Maessen, Paul Van Schil, Abhishek Saxena, Paraskevi Zisimopoulou, Konstantinos Lazaridis, Mark Woodhall, Katerina Karagiorgou, John Tzartos, Socrates Tzartos, Marc H. De Baets, Peter C. Molenaar, Alexander Marx, Axel zur Hausen, Mario Losen, Pilar Martinez-MartinezAbstractMyasthenia gravis (MG) is an autoimmune disease of the neuromuscular junction. Most patients have pathogenic autoantibodies against the acetylcholine receptor (AChR). In the last years a novel subpopulation of MG patients has been described that harbors antibodies against low-density lipoprotein receptor-related protein 4 (Lrp4), another postsynapt...

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