Gasdermin-d Played a Critical Role in the Cyclic Stretch –Induced Inflammatory Reaction in Human Periodontal Ligament Cells

In this study, it was found that GSDMD was activated by cyclic stretch, and its activation affected the pyroptotic rate in HPDLCs, leading to the maturation and secretion of IL-1β and IL-18 ultimately. In addition, GSDMD was f ound to be regulated by caspase-1 directly. Nevertheless, the exact relationship between inflammasomes and GSDMD in the stretch-induced inflammatory response still needs to be further elucidated. (Source: Inflammation)

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