Paracrine costimulation of IFN-{gamma} signaling by integrins modulates CD8 T cell differentiation [Immunology and Inflammation]

The cytokine IFN-γ is a critical regulator of immune system development and function. Almost all leukocytes express the receptor for IFN-γ, yet each cell type elicits a different response to this cytokine. Cell type-specific effects of IFN-γ make it difficult to predict the outcomes of the systemic IFN-γ blockade and... (Source: Proceedings of the National Academy of Sciences)

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