Back cover story: Eur. J. Immunol. 11'18

Our back cover features H&E staining of a section from a mouse eye with experimental autoimmune uveitis (EAU), induced by immunization with IRBP, a retinal ‐specific antigen. The image shows a portion of the retina, adjacent to the optic nerve head, with changes typical for EAU, namely, retinal folding, loss of photoreceptor cells and intense infiltration of inflammatory cells. The image is taken from Lyu et al. (pp. 1810–1816), where the authors show that treatment with the compound TMP778 inhibited the development of EAU. TMP778 is a specific inhibitor of RORγt, the transcription factor for IL‐17, but unexpectedly, the treatment inhibited the production of both IL‐17 and IFN‐γ. (Source: European Journal of Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PcGNO6