Identification and validation of a tumor-infiltrating Treg transcriptional signature conserved across species and tumor types [Immunology and Inflammation]

FoxP3+ T regulatory (Treg) cells are central elements of immunologic tolerance. They are abundant in many tumors, where they restrict potentially favorable antitumor responses. We used a three-pronged strategy to identify genes related to the presence and function of Tregs in the tumor microenvironment. Gene expression profiles were generated from... (Source: Proceedings of the National Academy of Sciences)

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