Molecular cloning and expression analysis of coagulation factor VIII and plasminogen involved in immune response to GCRV, and immunity activity comparison of grass carp Ctenopharyngodon idella with different viral resistance

Publication date: Available online 14 December 2018Source: Fish & Shellfish ImmunologyAuthor(s): Hongquan Wang, Chunhua Ding, Jing'an Wang, Xin Zhao, Shengzhen Jin, Jian Liang, Hong Luo, Dongfang Li, Rui Li, Yaoguo Li, Tiaoyi XiaoAbstractThe grass carp reovirus (GCRV) has been shown to cause lethal infections in the grass carp Ctenopharyngodon idella (C. idella). In order to investigate the immune response to GCRV infection, the full-length cDNA sequences of coagulation factor VIII (CiFVIII) and plasminogen (CiPLG) from C. idella were cloned and their involvement in the immune response was studied. The immunity factor levels in C. idella with different GCRV resistances were also analyzed. The full-length 2478 bp cDNA of CiFVIII contained an open reading frame of 1965 bp and encoded a putat...

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