Endoplasmic reticulum stress is involved in spiral ganglion neuron apoptosis following chronic kanamycin-induced deafness.

Authors: Tu Y, Fan G, Sun H, Cai X, Kong W Abstract Aminoglycoside antibiotics-induced hearing loss is a common sensorineural impairment. Spiral ganglion neurons (SGNs) are first-order neurons of the auditory pathway and are critical for the maintenance of normal hearing. In the present study, we investigated the time-course of morphological changes and the degeneration process of SGCs following chronic kanamycin-induced deafness and determined whether the endoplasmic reticulum (ER) stress was involved in the degeneration of SGNs. We detected density changes in SGCs and the expressions of Bip, IRE1α, ATF-6α, p-PERK, p-eIF2α, CHOP and caspase-12 at each time point after kanamycin treatment. TUNEL staining was also performed. The number of SGC deletions reached ~50% at the 70th da...

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