TGF β-1 and WNT signaling pathways collaboration associated with cochlear implantation trauma-induced fibrosis.

This study explores and highlights the collaboration between the TGF-β1 and WNT pathways in the trauma-initiated fibrotic process within the implanted cochlea. WNT signaling is involved in the development of the inner ear and therefore a potential target in hair cell regeneration therapies. However, in light of our observations from the current study, manipulation of the WNT pathway by gene therapeutic techniques in the pathological ear seems a very complex process with an increased risk of inducing excessive fibrosis thereby compromising the efficacy of implant function. This article is protected by copyright. All rights reserved. PMID: 30632705 [PubMed - as supplied by publisher] (Source: Anatomical Record)

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