Cockroach allergens: Coping with challenging complexity

The report by Glesner et  al1 studied the relative potency of 12 nonstandardized German cockroach extracts and 8 allergenic molecules (Bla g 1, 2, 4, 5, 6, 9, and 11 and Per a 7) by using direct human IgE antibody binding with ImmunoCAP assays and in-house competitive IgE antibody inhibition assays. Importantly, the invest igators included 3 new allergens (Bla g 6, 9, and 11) and used a robust study design involving individual sera, various extracts, and a comprehensive list of allergens. (Source: Journal of Allergy and Clinical Immunology)

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