Estrogen receptor α signaling promotes IL-17A production in Th17 cells through the Let7/IL-23R signaling pathway

Women have increased prevalence of severe asthma and increased CD4+ Th17 cells compared to men with severe asthma. Previously, we showed that 17 β-estradiol and progesterone (P4) increased IL-17A production in Th17 cells by decreasing Let-7f microRNA expression and increasing IL-23 receptor (IL-23R) expression. However, it was unclear how estrogen receptor (ER) signaling regulated this pathway. We hypothesize that ER signaling promotes IL-1 7A production in Th17 cells by negatively regulating let7f expression to increase IL-23R signaling. (Source: Journal of Allergy and Clinical Immunology)

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