In vivo tracking of rhesus macaque eosinophils to assess migration in response to glucocorticoids

Glucocorticoids (GC) remain the most commonly used therapy for eosinophil-associated disorders (EAD). Prolonged treatment is associated with significant side effects and resistance that commonly lead to drug discontinuation. Whereas rapid disappearance of blood eosinophils following a single dose of GC is characteristic, the mechanisms by which this occurs is unknown. To explore this, we developed a novel radiolabeling technique to track eosinophils following GC administration in vivo in a rhesus macaque model. (Source: Journal of Allergy and Clinical Immunology)

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