Steroid-Dependent Episodic Angioedema with Eosinophilia (Gleich Syndrome) in a Patient with Rheumatoid Arthritis

Episodic angioedema with eosinophilia, or Gleich syndrome, is a rare disorder characterized by periodic episodes of angioedema and leukocytosis with marked eosinophilia. Symptoms resolve spontaneously or are treated with corticosteroids as first-line therapy. Treatment of patients unresponsive to or dependent on corticosteroids is poorly defined. Several rheumatologic diseases, including rheumatoid arthritis (RA), can also present with elevated eosinophilia in blood or tissue. Here we present a case of steroid-dependent Gleich syndrome complicated by concurrent rheumatoid arthritis. (Source: Journal of Allergy and Clinical Immunology)

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