The significance of batch and patch test method in the establishing of contact allergy to fragrance mix I. EDEN fragrance study group

Background

A fragrance mix consisting of 8 separate fragrance ingredients (FM I) is present in most baseline patch test series. Patch testing using the TRUE Test technique is considered to detect less contact allergy to FM I than the Finn chamber technique.

Aim

To investigate the possible significance of the batch and patch test method in the establishing of contact allergy to FM I.

Method

3119 individuals representing a sample of the general population were patch tested with 2 batches of FM I with 2 patch test techniques at 6 dermatology clinics in 5 European countries. The TRUE Test technique and the Finn chamber technique with petrolatum preparations were used. McNemar's test was used for statistical calculations.

Results

The contact allergy prevalences varied between 0.7% and 2.6%. The patch tests with the mixes with Evernia prunastri (oak moss) with a high content of chloratranol/atranol resulted in substantially more positive reactions than the corresponding testing with the mixes with oak moss with a low content of chloratranol/atranol. The Finn chamber technique detected significantly more contact allergic reactions than the TRUE Test technique (P<0.001).

Conclusion

The Finn chamber technique detects more contact allergy to FM I than the TRUE Test technique.

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