β-Adrenergic signaling blocks murine CD8 + T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress

This study demonstrates that one mechanism by which β2-AR signaling can inhibit CD8+ T-cell activation  is by suppressing the required metabolic reprogramming events which accompany activation of these immune cells and thus reveals a new mechanism by which adrenergic stress can suppress the effector activity of immune cells. (Source: Cancer Immunology, Immunotherapy)

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