Publication date: Available online 18 September 2018Source: NeuroscienceAuthor(s): Amarins N. Heeringa, Calvin Wu, Christopher Chung, Michael West, David Martel, Leslie Liberman, M. Charles Liberman, Susan E. ShoreAbstractTinnitus alters auditory-somatosensory plasticity in the cochlear nucleus (CN). Correspondingly, bimodal auditory-somatosensory stimulation treatment attenuates tinnitus, both in animals and humans (Marks et al., 2018). Therefore, we hypothesized that tinnitus is associated with altered somatosensory innervation of the CN. Here, we studied the expression of vesicular glutamate transporters 1 and 2 (VGLUT1 and VGLUT2) in the CN, which reveals glutamatergic projections from the cochlea as well as somatosensory systems to this brainstem auditory center.Guinea pigs were unila...
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