Severe anaphylaxis to Propofol: first case of evidence of sensitization to soy oil.

We report a case of anaphylaxis to propofol in an adult patient without food allergy to soy, but with a latent sensitization to soy. An IgE-dependent allergy to propofol was established by a basophil activation test. Here, we document for the first time the existence of specific IgEs to a 65kDa protein, found in soybean oil and soy flour. In the absence of data on the reactogenic threshold for allergenic food proteins injected intravenously, a risk appears to be established and leads us to recommend a systematic detection for proteins in the refined soybean oil used in the pharmaceutical industry for intravenous products. PMID: 27152608 [PubMed - indexed for MEDLINE] (Source: European Annals of Allergy and Clinical Immunology)

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