Cationic red emitting fluorophore: A light up NIR fluorescent probe for G4-DNA

Publication date: Available online 11 October 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Beena Kumari, Akanksha Yadav, Sushree P. Pany, P.I. Pradeepkumar, Sriram KanvahAbstractGuanine (G) quadruplexes (G4) are nucleic acid secondary structures formed by G-rich sequences, which are commonly found in human telomeric and oncogene-promoter regions, and they have emerged as targets for regulation of multiple biological processes. Considering their importance, targeting the G-quadruplex structure with small molecular binders is extremely pertinent. In this work, red emitting water soluble fluorophores bearing push-pull substituents were synthesized and examined for their interaction with human telomeric G4 and duplex (ds) DNAs. The presence of a strong electron d...

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