IRF-1 Intervention in the Classical ROS-Dependent Release of NETs during LPS-Induced Acute Lung Injury in Mice

In conclusion, IRF-1 deficiency plays a key role in moderating the excessive NETs formedvia ROS in the classical pathway and retaining the protective role of the low-NET levels generated in early/rapid NETosis, which may serve as a novel target in acute lung injury/acute respiratory distress syndrome. (Source: Inflammation)

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