GSE118512 Induction of autonomous memory alveolar macrophages requires T-cell help and is critical to trained immunity

Contributors : Yushi Yao ; Mangalakumari Jeyanathan ; Siamak Haddadi ; Nicole G Barra ; Maryam Vaseghi-Shanjani ; Daniela Damjanovic ; Rocky Lai ; Sam Afkhami ; Yonghong Chen ; Anna Dvorkin-Gheva ; Clinton S Robbins ; Jonathan D Schertzer ; Zhou XingSeries Type : Expression profiling by arrayOrganism : Mus musculusInnate immune memory is a new important area of research. However, innate immune memory at the major mucosal sites remains poorly understood. Here we show that respiratory viral infection induces long-lasting memory alveolar macrophages (AM). Memory AM are programed to express high MHC II, carry a defense-ready gene signature, and produce, upon re-stimulation, neutrophil chemokines. Using a multitude of approaches, we reveal that the priming, but not maintenance, of memory AM req...

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