Molecular programs defining tumor-specific T cell dysfunction and therapeutic reprogrammability

Immunology Interest Group T cell responses to cancers differ depending on the nature of the target antigen: tumor antigens that are self-proteins are generally weakly immunogenic due to pre-existing self-tolerance, whereas tumor antigens that are tumor-specific (e.g. mutated proteins) are potentially highly immunogenic because the immune system has not been exposed to these antigens. We recently demonstrated that tumor-specific T cells differentiate to a non-responsive state following initial encounter with tumor antigen, even before the emergence of a pathologically-defined tumor. While this state is initially reversible, it progresses to a fixed state that cannot be rescued, and the reversible and fixed non-responsive states were defined by discrete chromatin states. This pathway resembl...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2D7dYvi