Bactericidal action of ferulic acid with ultraviolet-A light irradiation

Publication date: Available online 10 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Akihiro Shirai, Yu-ko YasutomoAbstractThe bactericidal activity of ferulic acid (FA) against various microorganisms was remarkably enhanced by ultraviolet-A (UV-A) irradiation (wavelength, 365 nm). However, the bactericidal mechanism in the photo-combination system has not been evaluated. In the present study, this combined treatment was characterized by investigating associated changes in cellular functions of Escherichia coli, including assessments of respiratory activity, lipid peroxidation, membrane permeability, and damage to DNA and the cell surface. FA adsorbed onto and was incorporated into bacterial membranes, and the affinity resulted in decreased respirato...

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