Eosinophils Display Subtype-specific Metabolic Profiles

Under homeostatic conditions and in disease progression eosinophils have a variety of effector functions regulating Local Immunity And/or Remodeling/Repair (LIAR hypothesis). These activities are manifestations of different eosinophil subtypes, which, in turn, depend on the cytokine milieu of the tissue microenvironment. Eosinophil subtypes are characterized by expression of specific genes and we hypothesize that their functions are supported by a distinct metabolic phenotype. The goal of this study was to examine relationships between Th1 or Th2 cytokine-dependent gene expression and parameters of energy metabolism in mouse eosinophils. (Source: Journal of Allergy and Clinical Immunology)

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