Topical Application of the Quaternary Ammonium Compound Didecyldimethylammonium Chloride Activates Type 2 Innate Lymphoid Cells and Initiates a Mixed-type Allergic Response

Didecyldimethylammonium chloride (DDAC) is an antimicrobial dialkyl-quaternary ammonium compound used in numerous products. Clinical data suggest that DDAC exposure elicits multiple types of hypersensitivity reactions; animal data supports a mixed-type response. Skin is a major route of exposure to chemicals; thus, we investigated immune responses in the skin to determine the mechanism behind DDAC-induced sensitization. (Source: Journal of Allergy and Clinical Immunology)

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