Mechanism of the photo-induced activation of CoC bond in methylcobalamin-dependent methionine synthase

Publication date: Available online 20 September 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Arghya Pratim Ghosh, Abdullah Al Mamun, Piotr Lodowski, Maria Jaworska, Pawel M. KozlowskiAbstractMethylcobalamin (MeCbl)-dependent enzyme methionine synthase (MetH), plays a critical role in the catalysis of methyl group transfer from methyltetrahydrofolate (CH3-H4folate) to homocysteine. It often performs a side reaction to generate cob(II)alamin through photolysis of the organometallic CoC bond. A hybrid QM/MM method has been applied to explore the photochemistry of MeCbl-bound MetH. The photolytic properties of MeCbl inside MetH are mediated by its manifold of low-lying excited states. The corresponding potential energy surfaces (PESs) of the electronically excite...

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