Combined PI3 K/mTOR Inhibition and Transcriptional Repression in Head and Neck Carcinoma

Objective: Head and neck squamous cell carcinoma (HNSCC) is the fifth most common cancer worldwide. Responses to targeted therapy for HNSCC have been observed to be modest because they are limited by tumor heterogeneity and adaptive resistance. Combination therapy has been proposed to mitigate the difficulties in sustaining responses to targeted therapy. Genomic characterization and preclinical studies have shown frequent phosphoinositide 3-kinase (PI3 K)/mammalian target of rapamycin (mTOR) pathway in HNSCC.

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