Haloperidol, Ziprasidone Found Ineffective in Treating Patients With Delirium in the ICU

Neither haloperidol nor ziprasidone, medications commonly used to treat psychosis, had any benefit over placebo in treating patients for delirium in the intensive care unit (ICU), according to astudy published Monday in theNew England Journal of Medicine."For more than 40 years, intravenous antipsychotic medications have been used to treat delirium in hospitalized patients," wrote E.W. Ely, M.D., of the Vanderbilt University Medical Center and colleagues. "In this double-blind, randomized, placebo-controlled trial of intravenous antipsychotic medications for the treatment of delirium in the ICU, there was no evidence that either haloperidol or ziprasidone led to a shorter duration of delirium and coma."The study involved patients with acute respiratory failure or shock who develope...

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