Regnase-1 controls colon epithelial regeneration via regulation of mTOR and purine metabolism [Immunology and Inflammation]

Damage to intestinal epithelial cell (IEC) layers during intestinal inflammation is associated with inflammatory bowel disease. Here we show that the endoribonuclease Regnase-1 controls colon epithelial regeneration by regulating protein kinase mTOR (the mechanistic target of rapamycin kinase) and purine metabolism. During dextran sulfate sodium-induced intestinal epithelial injury and acute... (Source: Proceedings of the National Academy of Sciences)

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