IgG4-Related Disease Mimicking Extranodal Lymphoma of the Hard Palatal Mucosa: A Case Report and Review of the Literature

Background: Immunoglobulin G4 (IgG4)–related disease is a rare fibroinflammatory disease first recognized as a systemic condition in 2003. The disorder is characterized by multiple tumor-like swellings, a lymphoplasmacytic infiltrate with numerous with IgG4-positive plasma cells, and fibrosis. Organs commonly involved include the pancreas, lungs, hepatobiliary tract, lymph nodes, and major salivary glands; involvement of the minor salivary glands of the mucosa of the hard palate has rarely been reported.

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