The End of the Binary Era: Revisiting the Spectrum of Tuberculosis.

Authors: Lin PL, Flynn JL Abstract Human Mycobacterium tuberculosis infection was thought to result in either active symptomatic tuberculosis (TB) or latent asymptomatic infection. It is now clear that this binary classification is insufficient to describe the myriad of infection outcomes. In active TB, symptomatic disease can be mild to severe, with a range of lung and thoracic lymph node involvement or extrapulmonary manifestations. Most humans control the infection and develop latent TB infection, with differential risks of reactivation to active TB. However, some frequently exposed persons appear to be resistant to infection, whereas others may initially become infected yet subsequently eliminate all bacilli. The immunologic factors influencing these varied outcomes are still n...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2z0RqIJ