Actinobacillus pleuropneumoniae triggers IL-10 expression in tonsils to mediate colonisation and persistence of infection in pigs

Publication date: Available online 22 October 2018Source: Veterinary Immunology and ImmunopathologyAuthor(s): Andrea Müllebner, Elena L. Sassu, Andrea Ladinig, Janna Frömbling, Ingrid Miller, Monika Ehling-Schulz, Isabel Hennig-Pauka, J. Catharina DuvigneauAbstractActinobacillus pleuropneumoniae(APP) persisting in clinically healthy pigs may be the causative agent of sudden outbreaks of severe respiratory disease in swine herds. During the course of acute disease, the pathogen is eliminated from inflamed lung tissue, which is characterized by the expression of pro-inflammatory cytokines and an influx of neutrophils. However, if clearance by the porcine immune system fails, APP may switch to a persistent form. At later stages of infection, the pathogen may reside in tonsillar tissue witho...

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